منابع مشابه
Tyramine-induced vasodilation mediated by dopamine contamination: a paradox resolved.
We reported previously that intravenous administration of tyramine induced a paradoxical forearm vasodilation and an increase in plasma dopamine, raising the possibility that dopamine is released by or converted from tyramine in vivo. Alternatively, tyramine can be nonenzymatically oxidized into dopamine in vitro, and this contamination may be responsible for the increase in plasma dopamine and...
متن کاملDopamine- and tyramine-based derivatives of triazenes: activation by tyrosinase and implications for prodrug design.
A range of triazene derivatives were synthesized and investigated as prodrug candidates for melanocyte-directed enzyme prodrug therapy (MDEPT). The prodrugs contained a tyramine or dopamine promoiety required for tyrosinase activation and this was joined via a urea functional group to the cytotoxic triazene. The stability of each of the prodrugs in phosphate buffer, human plasma and in mushroom...
متن کاملSpectrophotometric Determination of Dopamine in Pharmaceutical Formulations by Reaction with Tyramine
هصلاخلا ودلا ريدقتل هديدج هيفيط هقيرط ريوطت هساردلا هذه يف مت ملا يف نيماب ح تسملا و هيئاملا ليلا ح تارض هينلاديصلا . هدسكؤم ةدامك مويساتوبلا تادويرب اتيم دوجوب نيمرياتلا عم نيمابودلا لعافت ىلع هقيرطلا تدنتسا . تسيق يجوملا لوطلا دنع صاصتما ىصقا تطعاو ءاملا يف هبئاذلا هجتانلا هيوضعلا هغبصلا هيصاصتما 274 رتيمونان . تتاك هيطخلا نيبام 5.0 ىلا 45 مارغوركيام / لم , ناكف فشكلا دح اما 5.40 مارغو...
متن کاملAspergillus fumigatus contamination of lymphokine-activated killer cells infused into cancer patients.
Lymphokine-activated killer (LAK) cells, prepared by incubating autologous lymphocytes in cell culture medium with interleukin-2, selectively lyse tumor cells and are effective immunotherapy of some cancers. During a 3-month period, two patients at our center were infused with LAK cells subsequently found to have been contaminated by Aspergillus fumigatus. Each case was investigated by obtainin...
متن کاملCardiac effects of tyramine.
• Tyramino (p-hydroxyphenylethylamine), the product of decarboxylation of tyrosine, has been known for a number of years to have pharmacological activity as a pressor substance." In a preparation of the atrium of the cat's heart in Locke-Ringer solution, Ajidrus, in 1 924, showed that tyramine increased the rate aud amplitude of atrial contractions. In 1926, Tainter reported the circulatory eff...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2005
ISSN: 0009-9147,1530-8561
DOI: 10.1373/clinchem.2005.054361